Ischemia/Reperfusion With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans
نویسندگان
چکیده
Newgard Westhuizen, Joseph P. Mathew, Debra A. Schwinn, Donald D. Glower, Christopher B. Aslan T. Turer, Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, Johannes van der Ischemia/Reperfusion With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2009 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.108.816116 2009;119:1736-1746; originally published online March 23, 2009; Circulation. http://circ.ahajournals.org/content/119/13/1736 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org/content/suppl/2009/03/24/CIRCULATIONAHA.108.816116.DC1.html Data Supplement (unedited) at:
منابع مشابه
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.
BACKGROUND Human myocardial metabolism has been incompletely characterized in the setting of surgical cardioplegic arrest and ischemia/reperfusion. Furthermore, the effect of preexisting ventricular state on ischemia-induced metabolic derangements has not been established. METHODS AND RESULTS We applied a mass spectrometry-based platform to profile 63 intermediary metabolites in serial paired...
متن کاملThe Coronary Circulation as a Target of Cardioprotection
Myocardial ischemia/reperfusion injury affects not only the cardiomyocyte compartment but also all other cellular compartments, and the coronary circulation has a central role in it. Acute myocardial infarction most often arises from atherosclerotic plaque rupture/erosion with superimposed thrombosis (type 1 myocardial infarction). However, in the absence of coronary atherosclerosis, coronary v...
متن کاملThe Coronary Circulation as a Target of Cardioprotection
Myocardial ischemia/reperfusion injury affects not only the cardiomyocyte compartment but also all other cellular compartments, and the coronary circulation has a central role in it. Acute myocardial infarction most often arises from atherosclerotic plaque rupture/erosion with superimposed thrombosis (type 1 myocardial infarction). However, in the absence of coronary atherosclerosis, coronary v...
متن کاملThe Coronary Circulation as a Target of Cardioprotection
Myocardial ischemia/reperfusion injury affects not only the cardiomyocyte compartment but also all other cellular compartments, and the coronary circulation has a central role in it. Acute myocardial infarction most often arises from atherosclerotic plaque rupture/erosion with superimposed thrombosis (type 1 myocardial infarction). However, in the absence of coronary atherosclerosis, coronary v...
متن کاملThe Coronary Circulation as a Target of Cardioprotection
Myocardial ischemia/reperfusion injury affects not only the cardiomyocyte compartment but also all other cellular compartments, and the coronary circulation has a central role in it. Acute myocardial infarction most often arises from atherosclerotic plaque rupture/erosion with superimposed thrombosis (type 1 myocardial infarction). However, in the absence of coronary atherosclerosis, coronary v...
متن کامل